Femtosecond Structural Dynamics of Proteins

Proteins in Action: Femtosecond to Millisecond Structural Dynamics of a Photoactive Flavoprotein

Living systems are fundamentally dependent on the ability of proteins to respond to external stimuli. The mechanism, the underlying structural dynamics, and the time scales for regulation of this response are central questions in biochemistry. Here we probe the structural dynamics of the BLUF domain found in several photoactive flavoproteins, which is responsible for light activated functions a...

Computational Structural Dynamics of Proteins

Photoactivated structural dynamics of fluorescent proteins.

Proteins of the GFP (green fluorescent protein) family have revolutionized life sciences because they allow the tagging of biological samples in a non-invasive genetically encoded way. 'Phototransformable' fluorescent proteins, in particular, have recently attracted widespread interest, as their fluorescence state can be finely tuned by actinic light, a property central to the development of su...

Femtosecond conical intersection dynamics of tryptophan in proteins and validation of slowdown of hydration layer dynamics.

Water motion probed by intrinsic tryptophan shows the significant slowdown around protein surfaces, but it is unknown how the ultrafast internal conversion of two nearly degenerate states of Trp ((1)L(a) and (1)L(b)) affects the initial hydration in proteins. Here, we used a mini-protein with 10 different tryptophan locations one at a time through site-directed mutagenesis and extensively chara...

a structural survey of the polish posters

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